STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior
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چکیده
منابع مشابه
STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior
Experimental evidence suggests a role for the immune system in the pathophysiology of depression. A specific involvement of the proinflammatory cytokine interleukin 6 (IL6) in both, patients suffering from the disease and pertinent animal models, has been proposed. However, it is not clear how IL6 impinges on neurotransmission and thus contributes to depression. Here we tested the hypothesis th...
متن کاملCorrigendum: STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behaviour
DDP designed the study and wrote the manuscript. EK carried out molecular and biochemical analysis and wrote the manuscript. SS and FJM performed cell-culture and uptake assays. WFD assisted in gene expression analyses. GS carried out stereotactic surgeries and behavioral analysis. SNR, DK and MR performed behavioral experiments. FK carried out radioligand binding assays. MC assisted in biochem...
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The ubiquitin-proteasome system (UPS) controls the stability of most cellular proteins. The polymorphism of UPS-related genes is associated with major depression disorder, but less is known about the molecule that plays a role in depression by modulating the UPS. Melanoma antigen gene-D1 (MAGE-D1) interacts with RING E3 ubiquitin ligase and is implicated in protein degradation. MAGE-D1 may thus...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2015
ISSN: 2045-2322
DOI: 10.1038/srep09009